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KMID : 1134120100130010083
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Journal of Breast Cancer
2010 Volume.13 No. 1 p.83 ~ p.89
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Clinicopathological Characteristics in Invasive Ductal Breast Cancer with Low FDG Uptake in 18F-FDG PET/CT
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Seo Hyung-Il
Bae Young-Tae
Han Koon-Taek
Kim Seong-Jang
Park Do-Youn
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Abstract
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Purpose: The aim of this study is to evaluate whether low FDG uptake would be associated with the biological lowaggressiveness of invasive ductal carcinoma.
Methods: The subjects consisted of 124 female patients with primary invasive ductal carcinoma. All the patients were examined with 18F-FDG PET/CT before neoadjuvant chemotherapy.
Results: With regard to histopathologic grading, 117 were histopathologic grade 1 and 2, and 7 were grade 3. Low FDG uptake correlated with well and moderate histopathologic grade (p=0.003) and low 18F-FDG uptake in invasive ductal carcinoma depended on the presence of axillary lymph node metastases (p=0.014) and small tumor (<2.0 cm, p=0.022). Ki-67 positivity ranged from 0% to 60% (mean 15%). Sixty seven specimens showed low immunoreactivity to Ki-67 antigen (<10% of tumor cells). This revealed a significant correlation between low FDG uptake and Ki-67 (p=0.003). Logistic regression analysis between these factors showed that lower histologic grade, no axillary lymph nodes metastases and low Ki-67 (<10%) were correlated with low FDG uptake.
Conclusion: Our results demonstrated that an association exists between low FDG uptake and good prognostic factors such as lower histologic grade (1, 2), no axillary lymph node metastases and low Ki-67 (<10%).
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KEYWORD
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18F-FDG, Breast neoplasms, Positron-emission tomography/Computed tomography, Prognosis
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